This is our calculation, not a job specification. Rated CFM is the maker's figure, and real airflow with ducting and loaded filters is lower, which is what the allowance covers. When a project spec, a standard or a regulator sets the air change rate, that number wins.
How the ACH formula works
Air changes per hour is how many times the machines move a volume of air equal to the room's volume in one hour. Multiply length by width by height for the volume in cubic feet, then:
ACH = CFM × 60 ÷ room volume (cu ft)
CFM needed = room volume × target ACH ÷ 60
Machines = CFM needed ÷ (rated CFM × (1 - allowance)), rounded up
Example: a 40 by 30 by 10 ft space is 12,000 cu ft. At 4 air changes per hour it needs 12,000 × 4 ÷ 60 = 800 CFM. A machine rated at 750 CFM gives about 563 usable CFM after our 25% allowance, so the job takes 2 machines, which together give about 5.6 air changes per hour.
The clearing times use the CDC formula for a room with perfect mixing: minutes = ln(1 ÷ (1 - removal)) ÷ ACH × 60. At 4 ACH that is 69 minutes for 99% and 104 minutes for 99.9%, the same as the CDC's own table below the calculator. Real rooms mix less evenly, so treat these as the shortest likely times.